In toto labelling

Autofluorescence signals can be used to precisely define the anatomy and morphology of organs and complement classical histology, medical and functional imaging data, which are often less detailed.

Some or our clearing protocols preserve endogenous fluorescence emitted by fluorescent dyes or reporter proteins present in genetically modified organisms (GMOs)

Otherwise, detection of proteins or nucleic acids must include immunohistochemistry, however applying it to samples several cm thick remains technically demanding.